| Pic | Item | Description | Location in Leaf Green / Fire Red |
| Amulet Coin | Doubles earnings if Pokémon battles | Route 16 | |
| Antidote | Cures a Pokémon's poison condition | Some Poké Marts/ Viridian Forest/ Mt. Moon/ Celadon Dept. Store | |
| Awakening | Wakes Pokémon with a Sleep condition | Some Pokémon Marts/ Route 11/ Pokémon Tower/ Celadon Dept. Store | |
| Berry Pouch | A pouch for carrying Berries | First place where you get a berry | |
| Poké Ball | The basic ball used to catch Pokémon | Some Pokémon Marts/ Pallet Town/Viridian Forest | |
| Great Ball | Catches Pokémon better than a Poké Ball | Some Pokémon Marts/ SS Anne/ Route 11/ Pokémon Tower/ Celadon Dept. Store | |
| Master Ball | Always catches a Pokémon | Silph Co. | |
| Ultra Ball | Catches Pokémon better than Great Ball | Some Pokémon Marts/ Silph Col./ Seafoam Islands/ One Island Mt. Ember/ Four Island Icefall Cave/ Cerulean Cave | |
| Bicycle | Allows faster movement than the Running shoes | Cerulean City | |
| Bike Voucher | Exchange it for a Bicycle | Vermilion City | |
| Blackglasses | Increases power of Dark-type attacks | Team Rocket Hideout | |
| Coin Case | Holds coins for the Game Corner | Celadon City | |
| Dire Hit | Increases chance of a critical hit for one battle | Celadon Dept. Store/ One Island Mt. Ember | |
| Drink Lemonade | Restores 80 HP | Celadon Dept. Store/ Two Island Pokémon Mart | |
| Drink Soda Pop | Restores 60 HP | Celadon Dept. Store/ Two Island Pokémon Mart | |
| Drink Fresh Water | Restores 50 HP | Celadon Dept. Store/ Two Island Pokémon Mart | |
| Max Elixer | Restores 10 PP to all attacks | Pokémon Tower/ Power Plant/ Six Island Water Path | |
| Escape Rope | Provides a quick escape from caves | Some Pokémon Marts/ Mt. Moon/ Rock Tunnel/ Pokémon Tower/ Rocket Hideout/ Silph co./ Pokémon Mansion | |
| Ether | Restores 10 PP to one attack | Route 2/ SS Anne/ Celadon City/ One Island Kindle Road | |
| Max Ether | Restores all PP to one move | Rock Tunnel/ Rocket Hideout/ Three Island Berry Forest | |
| Everstone | Prevents a Pokémon from evolving | Route 10 | |
| Exp. Share | Gives Pokémon an extra share of experience | Route 15 | |
| Fame Checker | Records what you've heard about famous people | Cerulean City | |
| Helix Fossil | Changes into Omanyte at the Cinnabar Lab | Mt. Moon | |
| Guard Specific | Guards against special attacks for one battle | Celadon Dept. Store/ Victory Road | |
| Burn Heal | Heals a Pokémon's Burn condition | Some Pokémon Marts/ Route 9/ Celadon Sept. Store | |
| Full Heal | Cures all status conditions | Some Pokémon Marts/ Silph Co./ Three Island Berry Forest/ Victory Road | |
| Ice Heal | Heals a Pokémon's Freeze condition | Some Pokémon Mars/ Celadon Dept. Store/ Seafoam Islands | |
| Paralyze Heal | Heals a Pokémon's Paralyze condition | Some Pokémon Marts/Rout 2/ Mt. Moon/ Celadon Dept. Store | |
| Item Finder | Helps you find hidden items | Route 11 | |
| Card Key | Unlocks doors in Silph Co. | Silph Co. | |
| Lift Key | Operates the Team Rocket Hideout elevator | Rocket Hideout | |
| Secret Key | Opens Cinnabar Gym | Pokémon Mansion | |
| Tiny Mushroom | A payment to the Move Tutor | Itemfinder/ Wild Paras/ Wild Parasect | |
| Nugget | Sell for a high price | Route 24/ Pokémon Tower/ Safari Zone/ Seven Island Sevault Canyon/ Cerulean Cave | |
| Old Amber | Changes into Aerodactyl at the Cinnabar lab | Pewter City | |
|
Pearl |
Sell for a high price | Rock Tunnel/ Five Island Rocket Warehouse | |
| Big Pearl | Sell for a high price | Seafoam Islands/ Five Island Rocket Warehouse | |
| Poké Doll | Provides escape from a wild-Pokémon battle | Celadon Dept. Store | |
| Poké Flute | Wakes sleeping V | Lavender Town | |
|
Potion |
Restores 20 HP | Some Pokémon Marts/ Route 1/ Viridian City/ Viridian Forest/ Mt. Moon | |
| Super Potion | Restores 50 HP | Some Pokémon Marts/ SS Anne/ Celadon Dept. Store/ Rocket Hideout | |
| Hyper Potion | Restores 200 HP | Some Pokémon Marts/ Rocket Hideout/ Silph Co. | |
| Quick Claw | Increases chances of attacking first | Safari Zone | |
| Rainbow Pass | A ferry pass between Vermilion and the Sevii Islands | One Island | |
| Rare Candy | Raises Pokémon's level by one permanently | Mt. Moon/ Pokémon Tower/ Rocket Hideout/ Silph Co./ Fuchsia City/ Victory Road/ Five Island Lost Cave | |
| Repel | Repels weak Pokémon for 100 steps | Some Pokémon Marts/ Rock Tunnel | |
| Super Repel | Repels weak Pokémon for 200 steps | Some Pokémon Marts/ Celadon Dept. Store | |
| Max Repel | Repels weak Pokémon for 250 steps | Some Pokémon Marts/ One Island Kindle Road | |
| Full Restore | Cures all status conditions and restores all HP | Safari Zone/ Pokémon Mansion/ Three Island/ Four Island Icefall Cave/ Six Island/ Cerulean Cave | |
| Revive | Revives fainted Pokémon & restores 1/2 of its HP | Some Pokémon Marts/ Mt. Moon/ Rock Tunnel/ Celadon Dept. Store/ Seafoam Islands/ Two Island | |
| Max Revive | Revives a fainted Pokémon & restores all HP and PP | Silph Co./ Safari Zone/ Victory Road/ Five Island Lost Cave/ Cerulean Cave | |
| Good Rod | Fishes for more Pokémon than the Old Rod | Fuchsia City | |
| Old Rod | Lets you fish for Pokémon | Vermilion City | |
| Super Rod | Fishes for more Pokémon than the Good Rod | Route 12 | |
| Silph Scope | Identifies ghosts | Rocket Hideout | |
| SS Ticket | Used to board the SS Anne | Route 25 | |
| Star Piece | Sell for a high price | Mt. Moon/ Four Island/ Wild Staryu | |
| Stardust | Sell for a high price | SS Anne/ Cinnabar Island (trade for Tangela)/ Four Island/ Wild Staryu | |
| Fire Stone | Evolves specific Pokémon | Celadon Dept. Stone/ Once Island Mt. Ember | |
| Leaf Stone | Evolves specific Pokémon | Celadon Dept. Store/ Safari Zone | |
| Moon Stone | Evolves specific Pokémon | Mt. Moon/ Rocket Hideout/ Two Island/ Wild Clefairy | |
| Thunderstone | Evolves specific Pokémon | Celadon Dept. Store/ Power Plant | |
| Water Stone | Evolves specific Pokémon | Celadon Dept. Store/ Seafoam Islands | |
| Tea | Slakes even the worst thirst | Celadon Mansion | |
| Teachy TV | Broadcasts useful tips for novice Trainers | Viridian City | |
| TM Case | Holds TMs and HMs | Place where you first obtain a TM or HM | |
| Town Map | A map of Kanto that shows your present location | Pallet Town | |
| Tri-Pass | A ferry pass between Vermilion City, One, Two and Three Islands | One Island, Vermilion City | |
| Vs. Seeker | A device that shows Trainers who want to battle | Vermilion City | |
| X Accuracy | Increases Accuracy for one battle | Pokémon Tower/ Celadon Dept. Store | |
| X Attack | Increases Attack for one battle | SS Anne/ Celadon Dept. Store | |
| X Defend | Increases Defend for one battle | Route 11/ Celadon Dept. Store | |
| X Special | Increases Special Attack for one battle | Celadon Dept. Store/ Silph Co. | |
| X Speed | Increases Speed for one battle | Celadon Dept. Store/ Rocket Hideout | |
| Vitamin Calcium | Raises Special Attack permanently | Cerulean City/ Celadon Dept. Store/ Rocket hideout/ Silph Co./ Pokémon Mansion | |
| Vitamin Carbos | Raises Speed Permanently | Cerulean City/ Celadon Dept. Store/ Pokémon Mansion/ One Island Kindle Road | |
| Vitamin HP Up | Raises maximum HP permanently | Cerulean City/ Celadon Dept. Store/ Silph Co. / Pokémon Mansion/ Six Island | |
| Vitamin Iron | Raises Defense permanently | Cerulean City/ Celadon Dept. Store/ Silph Co./ Route 12/ Pokémon Mansion | |
| Vitamin Protein | Raises Attack permanently | Cerulean City/ Celadon Dept. Store/ Silph Co./Safari Zone/ Pokémon Mansion | |
| Vitamin Zinc | Raises Special Defense Permanently | Cerulean City/ Celadon Dept. Store/ Silph Co./ Pokémon Mansion/ Three Island |